Resources

Progress in science depends on new techniques, new discoveries and new ideas, probably in that order.

Online resources:

  1. The Myeloid Landscape 2 (Link)

    • These reports accompany our manuscript "Alzheimer's patient brain myeloid cells exhibit enhanced aging and unique transcriptional activation" describing gene expression in purified CNS cells from Alzheimer's and control subjects, and also integrate the data sets from our previous manuscript "Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models". The companion website from the earlier manuscript Myeloid Landscape 1 is still available at that archival link.

  2. Brain RNA-Seq (Link)

    • BrainRNAseq is a site dedicated to sharing scientific data. From its inception, our goal has always been to create a database that was simple to use, access, and interpret. To that end, we have curated datasets that are amenable to quick and easy interpretation. We hope these data will be valuable to you and your work. Because of the simplicity of this site, we encourage you to supplement the information here with the numerous other databases that exist in the space of brain transcriptomics / proteomics.

  3. Microglia Gene List Enrichment Calculator (Link)

    • Database of microglial gene expression profiles across a number of conditions for users to compare against enriched genes from a personal dataset.

Public datasets:

  1. ABC Atlas (Link)

    • The Allen Brain Cell (ABC) Atlas provides a platform for visualizing multimodal single cell data across the mammalian brain and aims to empower researchers to explore and analyze multiple whole-brain datasets simultaneously. This open science resource, developed by the Allen Institute as part of the Brain Knowledge Platform, allows unprecedented insights into the enormous diversity of cell types in the brain and where they are.

  2. Human Cell Atlas Explorer (Link)

    • The Human Cell Atlas (HCA) community is profiling millions of human cells, a process that generates enormous amounts of data that scientists need to store, standardize and interpret. To help coordinate this data collection and processing, the HCA established the HCA Data Portal, a public, cloud-based platform where scientists can share, organise and interrogate single-cell data.

  3. The Brain Immune Atlas (Link)

    • The brain immune atlas provides a resource and visualization tool for assessing the single-cell RNA sequencing datasets generated by the Movahedi lab, which capture human and mouse brain immune cells in health and disease. You can visualize the expression of individual genes and/or download differentially expressed gene lists that define immune cell clusters.

  4. CZ CELLxGENE (Link)

    • CELLxGENE is a suite of tools that help scientists to find, download, explore, analyze, annotate, and publish single cell datasets. It includes several powerful tools with various features to help you to engage with single cell data.

  5. Single Cell Portal (Link)

    • Single Cell Portal facilitates sharing scientific results, and disseminating data generated from single cell technologies. We strive to make open science and open data interactive, easy, and powerful. We hope you will be a part of this amazing effort for science.

  6. Panglao DB (Link)

    • Database of microglial gene expression profiles across a number of conditions for users to compare against enriched genes from a personal dataset.

  7. The Mouse Brain Atlas (Link)

Conferences & Webinars:

  1. European Microglia Webinar Series (Link)

    • The EMWS created by Guy Brown (University of Cambridge) is currently organized by a group of researchers from the University of Lausanne, the Collège de France, and ACHUCARRO.

  2. Online Seminars:

    • Beth Stevens #1: Microglia States in Health and Disease (Link)

    • Beth Stevens #2: How Microglia Sculpt Brain Circuitry in Health and Disease (Link)

    • Beth Stevens: Redefining Microglia States and Function in Alzheimer’s Disease (Link)

    • Bess Frost: Transposable Element Activation in Neurodegenerative Tauopathy: From Bench to Bedside (Link)

    • David Holtzman: Sleep & the Pathophysiology of Alzheimer's Disease (Link)

    • Ben Barres: What do reactive astrocytes do? (Link)

    • Bo Peng: Microglia replacement: from bench to clinical therapy (Link)

    • Marco Prinz: The myeloid side of brain (Link)

    • Martin Kampmann: Multiplexing with CRISPR Screens (Link)

    • Jennifer Doudna: CRISPR-Cas9: From Biology to Transformative Technology (Link)

    • Anna Molofsky: Regulation of microglial function by cytokines (Link)

    • Anne Schaefer: Negative feedback control of neuronal activity by microglia (Link)

    • Marius Wernig: Next generation cell therapies for the brain, NHGRI DIR Seminar Series (Link)